An Introduction to Genetic Analysis by Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll,

By Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley

With each one version, An creation to Genetic research (IGA) evolves discovery by means of discovery with the area of genetic study, taking scholars from the rules of Mendelian genetics to the most recent findings and purposes via concentrating on the landmark experiments that outline the field.

With its writer staff of popular scientists who're additionally hugely finished educators, IGA back combines unparalleled forex, expansive updating of its acclaimed challenge units, and quite a few new how one can study genetics. greatest is that this edition’s committed model of W.H. Freeman’s step forward on-line direction area, LaunchPad, which deals a couple of new and superior interactive instruments that strengthen IGA’s middle venture: to teach scholars how one can study experimental information and draw their very own conclusions in accordance with medical pondering whereas instructing scholars tips on how to imagine like geneticists. See what is within the LaunchPad

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In 2012, advances in genomics and DNA sequencing technology (see Chapter 14) allowed new analyses proving that Weinberg’s and Haldane’s suspicions were correct and providing a very detailed picture of the origin of new mutations within families. Here is how it was accomplished. A team of geneticists in Iceland studied 78 “trios”—a family group of a mother, a father, and their child (Figure 1-16). For some families, they had data for three generations, including a child plus its parents and at least one set of grandparents.

How do genes function inside cells in a way that enables them to control different states for a trait like flower color? In 1941, Edward Tatum and George Beadle proposed that genes encode enzymes. Using bread mold (Neurospora crassa) as their experimental organism, they demonstrated that genes encode the enzymes that perform metabolic functions within cells (Figure 1-7). In the case of the pea plant, there is a gene that encodes an enzyme required to make the purple pigment in the cells of a flower.

In several cases, the DNA data for the child and parents also allowed the researchers to identify specific new mutations in genes that likely caused the disorder. For example, one child with autism inherited a new mutation in the EPH receptor B2 (EPHB2) gene that functions in the nervous system and in which a mutation had previously been found in an autistic child. Studies such as this can have important implications for individuals and society. Some men who intend to delay parenting until later in life might choose to freeze samples of their sperm while still young.

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